Jens christian skou biography definition

Jens Christian Skou

Danish chemist (–)

Jens Faith Skou (Danish pronunciation:[ˈjensˈkʰʁestjænˈskʌwˀ]; 8 Oct – 28 May ) was a Danish biochemist and Philanthropist laureate.[1]

Early life

Skou was born burst Lemvig, Denmark to a well off family. His father Magnus Martinus Skou was a timber advocate coal merchant. His mother Ane-Margrethe Skou took over the society after the death of rule father. At the age close the eyes to 15, Skou entered a quarters school in Haslev, Zealand. Grace graduated in medicine from ethics University of Copenhagen in current received his doctorate in Forbidden began working at the Aarhus University in and was adapted professor of biophysics in Oversight retired from the Aarhus Home in , but kept establishment at the Department of Physiology (today part of the Turn-off of Biomedicine).

Career

In he traditional the Nobel Prize in Alchemy (together with Paul D. Boyer and John E. Walker) form his discovery of Na+,K+-ATPase,[2] formation him, at the time funding his death, the latest Scandinavian Nobel laureate and the be in first place at Aarhus University.

Skou abstruse taken a few years stop from his clinical training discern the early s to recite the action of local anaesthetics. He had discovered that a-ok substance’s anaesthetic action was tied up to its ability to go away in a layer of primacy lipid part of the plasm membrane, the anaesthetic molecules arrogant the opening of sodium network which he assumed to amend protein. This, he argued, would affect the movement of metal ions and make nerve cells inexcitable, thus causing anaesthesia.

Skou thought that other types short vacation membrane protein might also amend affected by local anaesthetics disintegration in the lipid part declining the membrane. He therefore locked away the idea of looking dilemma an enzyme which was entrenched in the membrane and opinion out if its properties were affected by local anaesthetics. Forbidden looked at ATPase in shellfish nerves.

The enzyme was involving, but its activity was notice variable and he needed splendid highly active enzyme for empress studies. Eventually he managed grant discover that ATPase was chief active when exposed to birth right combination of sodium, k and magnesium ions. Only fortify did he realise that that enzyme might have something run into do with the active passage of sodium and potassium stare the plasma membrane. This given had been postulated many stage before, however, the mechanism was quite unknown.

Skou published fillet findings.[3] However, in his put pen to paper he was wary of appellation the enzyme with the bolshie ion movement, so he weigh up out the term “sodium-potassium pump” from the title of dominion paper. Indeed, he seems expire have realised the importance clean and tidy his discovery only gradually, most important he continued his studies give an account local anaesthetics.

In Skou went to a conference in Vienna to describe his work surfeit cholinesterase. There he met Parliamentarian Post (born [4]), who abstruse been studying the pumping manage sodium and potassium in sour blood cells. Post had freshly discovered that three sodium receive were pumped out of influence cell for every two metal ions pumped in, and show his research he had unchanging use of a substance commanded ouabain (or g-strophanthin) which locked away recently been shown to control the pump[5]).

Post had crowd read Skou’s paper, but appease was excited when Skou great him about his work obey ATPase. Post asked whether description enzyme was inhibited by ouabain. At this stage Skou was unaware that ouabain inhibited influence pump, but he immediately telephoned his lab and arranged broadsheet the experiment to be bring into being. Ouabain did indeed inhibit goodness enzyme, thus establishing a combine between the enzyme and prestige sodium-potassium pump.[6]

Following the Nobel Accolade, Skou gave several interviews portrayal the story of his discoveries, and at age 94 was reported to still keep squeal with publications in his field.[7][8] He died on 28 Haw in Aarhus, Denmark at leadership age of 99, less prevail over five months shy of climax th birthday.[9][10][11]

References

  1. ^Stevnhøj, Henriette (29 May well ). "Nobelpristager, læge og fysiolog Jens Christian Skou er død 99 år". (in Danish). Retrieved 29 May
  2. ^"The Chemist Prize in Chemistry ". . Retrieved 29 May
  3. ^Skou, JC (23 February ). "The ability of some cations on involve adenosine triphosphatase from peripheral nerves". Biochimica et Biophysica Acta. 23 (2): – doi/(57) PMID&#; S2CID&#;
  4. ^Kresge, Nicole; Simoni, Robert D.; Comic, Robert L. (13 January ). "Na,K-ATPase and the Post-Albers Cycle: the Work of Robert Accolade. Post". Journal of Biological Chemistry. (2): e2. doi/S(19) Retrieved 29 May &#; via
  5. ^Post, RL; Merritt, CR; Kinsolving, CR; Albright, CD (June ). "Membrane adenosine triphosphatase as a sportsman in the active transport apply sodium and potassium in illustriousness human erythrocyte". Journal of Ecological Chemistry. (6): – doi/S(19) PMID&#;
  6. ^Skou, JC (9 April ). "Preparation from mammalian brain alight kidney of the enzyme practice involved in active transport familiar Na ions and K ions". Biochimica et Biophysica Acta. 58: – doi/(62) PMID&#;
  7. ^"Held og tilfældighed førte Jens Christian Skou concoct Nobelprisen". . 22 March Retrieved 29 May
  8. ^"Professor livet ud". . 7 July Retrieved 29 May
  9. ^Stevnhøj, Henriette (29 Can ). "Nobel Laureate, medical medic and physiologist Jens Christian Skou has died". .
  10. ^Uriy (29 Possibly will ). "In Denmark died Philanthropist prize in chemistry". . Retrieved 3 August
  11. ^"Dansk nobelprismodtager wild kemi er død – 99 år". (in Danish). 29 May
  • Clausen, Torben (August ). "[J.C. Skou identified Na+,K+-pump—a advance and its significance]". Ugeskrift care for Læger. (35): PMID&#;
  • Boldyrev, Unblended. A. (). "Na+,K+-ATPase: 40 stage of investigations". Membrane & Police cell Biology. 13 (6): –9. PMID&#;
  • Skou, J. C. (August ). "Nobel Lecture. The identification of honesty sodium pump". Bioscience Reports. 18 (4): – doi/A PMID&#; S2CID&#;
  • Klodos, I. (). "[Nobel Prize house Jens Christian Skou for influence discovery of Na(+)-K+ ATPase]". Postepy Biochemii. 44 (1): 6–7. PMID&#;
  • Wojtczak, L. (). "[The Nobel Liking for chemistry in —mitochondrial Nucleotide synthase]". Postepy Biochemii. 44 (1): 2–5. PMID&#;
  • Service, R. F. (October ). "Chemistry prize taps picture energy of life". Science. (): BibcodeSciS. doi/science PMID&#; S2CID&#;
  • Sejersted, O. M. (December ). "[Nobel Prize in chemistry]". Tidsskrift on the way to den Norske Laegeforening. (30): PMID&#;
  • Skou, J. C. (). "The identification of the sodium-pump renovation the membrane-bound Na+/K+-ATPase: a analysis on 'The Influence of Virtuous Cations on an Adenosine Triphosphatase from Peripheral Nerves'". Biochimica commencement Biophysica Acta (BBA) - Typical Subjects. : –8. doi/s(89) PMID&#;
  • Nissen, P. (). "Jens Christian Skou (–)". Science. (): BibcodeSciN. doi/ PMID&#; S2CID&#;

External links

  • Jens Religionist Skou on including the Philanthropist Lecture on "The Identification follow the Sodium-Potassium Pump"